什么是cancer vulnerability？缺点，
什么是Cancer Dependency？依赖
什么是viability？生存
什么是susceptibility？易感性
什么是synthetic lethality？就是两个基因任何一个单独不致死，两个基因都突变才致死，已有成功药物。
Cancer cells often have mutations in anticancer genes that make their survival dependent on other genes.
The gene-editing approach CRISPR–Cas9 offers a way to identify such vulnerabilities.
certain tumours that have deficiencies in a type of DNA-repair process require an enzyme called Werner syndrome ATP-dependent helicase (WRN) for their survival.
If inhibitors of WRN are found, such molecules might be promising drug candidates for further testing.
However, loss-of-function mutations can render cancer cells dependent on specific genes through a principle known as synthetic lethality
These and other successes have inspired many efforts to search for synthetically lethal genetic relationships involving commonly mutated tumour-suppressor genes such as TP53, PTEN and RB1.
参考：
- Lethal clues to cancer-cell vulnerability
- Synthetic lethality | Synthetic Lethal Interactions | BRCA Mutation & PARP Inhibition
- Cancer Vulnerabilities Unveiled by Genomic Loss - CELL
标签：synthetic,vulnerability,Cancer,dependent,genes,viability,lethality From： https://www.cnblogs.com/leezx/p/17011616.html