Goodpasture syndrome 肺出血伴肾小球肾炎又称抗基膜性肾小球肾炎、Goodpasture综合征或Goodpasture病。它是由抗基膜抗体导致的肾小球和肺泡壁基膜的严重损伤，临床表现为肺出血、急进性肾小球肾炎和血清抗肾小球基膜（GBM）抗体阳性三联征。多数患者病情进展迅速，预后凶险。 Goodpasture于1919年首先作了在一次暴发性流感中的肾小球损伤合并肺出血的报道。Stanton和Tange于1958年又报道一组肺出血合并新月体性肾小球肾炎的病例，并命名为Goodpasture综合征。我国于1965年首次报道并正式列入医学文献。确定本病有肾小球和肺泡壁的毛细胞血管基膜有线状免疫球蛋白沉积，1967年确定了抗基膜抗体在本病发病机制中所起的重要作用。 肺出血伴肾小球肾炎治疗采取综合疗法。血浆置换与皮质激素和环磷酰胺等合并使用，即可清除和降低血清抗肾基膜抗体浓度，同时可清除对体内组织有损伤的物质α、β补体等，从而减轻和改善肾和肺的病变。血浆置换和激素免疫抑制剂无效病例，可考虑双肾切除。肺出血明显者以腹膜透析为宜。透析过渡几个月或半年以上，一但血液内抗肾基膜抗体消失后可施行肾移植，可避免移植肾复发肾炎发生。 Goodpasture syndrome is a rare autoimmune disorder免疫系统混乱 that affects the lungs肺 and kidneys肾. It is caused by the immune system attacking the basement membrane膜, a layer of tissue that supports the cells of the respiratory呼吸 and renal肾脏 systems. This attack causes inflammation炎症 and damage to the lungs and kidneys, leading to symptoms such as coughing, difficulty breathing, and blood in the urine. Goodpasture syndrome is named after the American pathologist Ernest Goodpasture, who first described the condition in 1919. There is no cure for Goodpasture syndrome, but treatment with medications and therapies can help manage the symptoms and prevent further damage to the lungs and kidneys. Goodpasture syndrome is an autoimmune disorder. This means that the body's immune system, which is normally responsible for protecting against foreign invaders like bacteria and viruses, mistakenly attacks healthy tissue. In the case of Goodpasture syndrome, the immune system attacks the lungs and kidneys.
What's the factors of Goodpasture syndrome? Why the immune system attack the people self?
The exact causes of Goodpasture syndrome are not fully understood, but it is thought to result from a combination of genetic and environmental factors. Some people may have a genetic遗传的 predisposition (易患某种病的)体质 to the disorder, which means that they are more likely to develop it due to inherited traits from their parents.
In addition, certain environmental triggers, such as infections or exposure to certain chemicals, may cause the immune system to mistakenly attack healthy tissue. It is also possible that Goodpasture syndrome may develop as a complication of another autoimmune disorder.
Overall, the exact factors that lead to the development of Goodpasture syndrome are not well understood and may vary from person to person.
Is it possible the HIV caused the Goodpasture syndrome ?
It is unlikely that HIV would cause Goodpasture syndrome. Goodpasture syndrome is an autoimmune disorder, which means that it is caused by the body's own immune system mistakenly attacking healthy tissue. HIV, on the other hand, is a viral infection that attacks the immune system itself, making it less able to fight off other infections.
While it is possible for someone with HIV to develop an autoimmune disorder, there is no known direct link between HIV and Goodpasture syndrome. If you are concerned about your risk of developing Goodpasture syndrome, it is important to discuss your concerns with a healthcare provider. They can provide more information and help you understand your individual risk.
标签：基膜,syndrome,system,Goodpasture,肾炎,肺出血,肾小球 From： https://www.cnblogs.com/chucklu/p/16977238.html